Description
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9.
Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.
The CC cytokines are proteins characterized by two adjacent cysteines.
The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes.
This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites.
It specifically binds to chemokine receptor 10 (CCR10).
Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation